Cytochrome P-450 in Human Fetal Liver. Properties of P-450 HFLa, a Form of Cytochrome P-450 in Human Fetal Livers
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چکیده
منابع مشابه
Sequence of a human liver cytochrome P-450 cDNA clone.
The following nucleotide sequence (P450 HPH) has been cloned from cDNA library of adult human liver in Xgtll by immunoscreening method. We used polyclonal antibodies against cytochrome P-450 from phenobarbital-pretreated rats. The sequence is essentially identical to the sequences Hpl — 1 and M-12 described by (1) and (2) respectively for the P-450 IIC8 type gene. The sole difference in the tra...
متن کاملDistribution of cytochromes P-450, cytochrome b5, and NADPH-cytochrome P-450 reductase in an entire human liver.
In rat liver there appear to be significant differences between lobes in the concentration of individual cytochrome P-450 isozymes (Sumner and Lodola, Biochem Pharmacol 36: 391-393, 1987). Because studies in patients often rely on small pieces of liver obtained from diverse anatomical locations, it seemed important to determine if the cytochromes P-450 were also heterogeneously distributed in h...
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The presence of a very active cytochrome P-450-dependent drug-metabolizing system in the olfactory epithelium has been confirmed by using 7-ethoxycoumarin, 7-ethoxyresorufin, hexobarbitone and aniline as substrates, and the reasons for the marked activity of the cytochrome P-450 in this tissue have been investigated. The spectral interaction of hexobarbitone and aniline with hepatic and olfacto...
متن کاملQuantification of cytochrome P-450 gene expression in human tissues.
Humans can metabolize an extremely wide range of potentially harmful foreign hydrophobic compounds including many drugs, environmental pollutants and chemical carcinogens. This ability is mainly due to the action of cytochromes 1’-450. These proteins constitute a large superfamily that has been classified into several families, the largest of which (P45011) has been further divided into seven s...
متن کاملInteraction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid.
Phospholipid has been reported to be necessary for optimal catalytic activity of a number of mammalian cytochrome P-450 (P-450) systems. We also confirm that a number of individual phospholipids and mixtures, used as soluble monomers or phospholipid vesicles, show activation of 7-ethoxycoumarin O-deethylase activity by an enzyme system composed of rat liver microsomal P-450PB-B and NADPH-P-450 ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1991
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.111.3_158